The Hard to Wet Surfaces (Eli Lilly-Hard to Wet Surfaces) investigation is simple, safe, and similar to the standard dissolution experiments run at Eli Lilly. Observing the performance of mini-tablet wetting and dissolution in a controlled situation in a vial helps to establish increased understanding of how a tablet/formulation performs in-vivo.
On earth, the density differences between a hard-to-wet solid/tablet and the solution can result in the solid/tablet floating on top of the solution, thereby exacerbating the dissolution problem. In microgravity, the solid/liquid density differences are negligible, and other factors controlling dissolution rate such as wettability dominate.
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