
Predicting the effects of spaceflight on the human body can be very
challenging. Humans have not spent enough time in reduced gravity
to accurately determine the risk of health problems for future exploration
missions.
As NASA plans for longer, more physically demanding missions,
mission planners need to better understand how human physiology is altered
during spaceflight to establish health and safety requirements for
these new missions. To this end, NASA has conceived of the Digital
Astronaut Project. The Digital Astronaut Project, led out of
the Johnson Space Center and in partnership with Glenn Research Center
and the University of Mississippi Medical Center, is an effort to
create a detailed computer model of the entire human physiological
function that can be used to predict the effects of spaceflight on
each physiological system. All body systems, such as the cardiovascular
and vestibular systems, will be simulated at the level of detail required
to understand the effects of spaceflight.
As part of this computational
effort, Glenn is responsible for creating detailed modules that predict
functional cardiac changes, alterations in bone remodeling physiology
and changes in muscle activation resulting from extended duration
reduced gravity exposure. Additionally,
Glenn recently completed work on a module simulating renal stone formation
and transport in microgravity.
In addition to these detailed models,
Glenn is also responsible for leading project wide verification and
validation of the integrated model. Glenn leads the effort in setting processes used to insure
that predictions made by each simulation are as computationally accurate
and physiologically well-founded as possible. Additionally,
validation efforts led by the GRC team will help quantify the operational
limits over which Digital Astronaut simulations can be used to inform
researchers and decision makers regarding the physiological risks
involved with space flight.
Glenn was selected for these roles in the
project because of the center’s longstanding expertise in creating
integrated computational simulations, especially in the areas of finite
element and fluids structure interaction simulations.
As an ongoing
part of these simulations, the Digital Astronaut will reflect the
effects of reduced gravity so the body’s reaction
to spaceflight can be determined. Then, health problems can be studied
to see how the body would respond in a reduced gravity environment.
Glenn’s
contributions to the development of the Digital Astronaut will help
determine the safety of astronauts during future missions to the moon
and Mars. The computer model of the human physiology will also be
useful to the medical community because it will aid in understanding
disease, perhaps leading to improvements in pharmaceuticals, surgical
procedures and treatments. The Digital Astronaut may also become a
beneficial teaching aid in medical schools.
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M-Mode
ultrasound image of cardiac tissue. |
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Computational
representation of cardiac tissue corresponding to the
ultrasound image. |
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Three-dimensional
model of the human heart. |
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Polarized
light image of human aortic valve leaflet. |
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Computational
representation of aortic valve. |
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